Product name: Superdrol — Paragon Pharmatech
Strength per capsule: 10 mg Superdrol
Capsules per bottle: 60 vegetarian capsules

Other names: Methasterone; Methyldrostanolone; 2α,17α-dimethyl-5α-androstan-17β-ol-3-one; designer anabolic steroid; DHT‑derived anabolic agent

CAS number: 3381-88-2

Chemical structure (summary):
Superdrol (methasterone) is a synthetic derivative of dihydrotestosterone (DHT) characterized by 17α‑methylation, which allows oral bioavailability, and 2α‑methyl substitution, which alters anabolic and androgenic activity. The molecule contains a steroid nucleus composed of four fused cycloalkane rings with a ketone group at C3 and hydroxyl group at C17.

Molecular formula: C21H34O2
Molecular weight: 318.49 g/mol
Chemical class: 17α‑alkylated anabolic‑androgenic steroid (AAS), DHT derivative

10 Strong Points & Benefits 

1. Demonstrates strong anabolic activity in experimental and historical pharmacologic studies of DHT‑derived compounds.

2. Oral bioavailability due to 17α‑alkylation allows pharmacokinetic and endocrine research without parenteral administration.

3. DHT‑derived structure prevents aromatization to estrogen, enabling research on androgenic signaling without estrogenic conversion.

4. Potent stimulation of protein synthesis pathways observed in cellular and animal models of androgen receptor activation.

5. Increased nitrogen retention and lean tissue accretion documented in studies of comparable anabolic agents.

6. Useful experimental model for studying androgen receptor signaling and muscle hypertrophy pathways.

7. Demonstrates measurable effects on erythropoiesis and hematologic parameters in androgen research.

8. Provides insights into lipid metabolism and hepatic enzyme responses to 17α‑alkylated steroids.

9. Valuable research tool for examining endocrine feedback mechanisms and HPG axis suppression.

10. Chemically stable small molecule suitable for analytical characterization using HPLC, GC‑MS, and NMR methods.

Overview

Superdrol (methasterone) is a synthetic anabolic‑androgenic steroid derived from dihydrotestosterone and structurally related to drostanolone. It was originally described in pharmaceutical literature in the mid‑20th century but was never widely marketed as a prescription medication. In the early 2000s it appeared in dietary supplement markets before being prohibited in multiple jurisdictions due to its pharmacologic potency and potential toxicity.

From a scientific perspective, methasterone is notable for its strong anabolic properties and resistance to aromatization. The compound binds to androgen receptors in skeletal muscle and other tissues, promoting transcription of genes involved in protein synthesis, nitrogen retention, and cellular growth.

Research interest in compounds such as methasterone extends beyond performance physiology into endocrinology, hepatology, and cardiovascular research. 17α‑alkylated anabolic steroids are frequently used as models for studying hepatic metabolism, lipid alterations, and hormonal feedback mechanisms.

Paragon Pharmatech manufactures Superdrol capsules under controlled conditions with identity, purity, and potency testing suitable for laboratory and scientific research applications.

How It Works 

Androgen Receptor Activation

Superdrol binds to intracellular androgen receptors, forming a ligand‑receptor complex that translocates to the nucleus and regulates transcription of androgen‑responsive genes. These genes influence protein synthesis, satellite cell activation, and muscle fiber hypertrophy.

Protein Synthesis and Nitrogen Retention

Activation of androgen signaling increases ribosomal activity and translational efficiency, resulting in increased synthesis of contractile proteins such as actin and myosin. Nitrogen retention improves the anabolic environment of skeletal muscle tissue.

Erythropoiesis and Hematologic Effects

Androgens stimulate erythropoietin production and bone marrow activity, increasing red blood cell mass and hemoglobin levels in experimental studies.

Lipid and Metabolic Effects

17α‑alkylated anabolic steroids commonly reduce HDL cholesterol and may increase LDL cholesterol. These effects are widely documented and provide a model for studying steroid‑induced dyslipidemia.

Hepatic Metabolism

Oral anabolic steroids undergo hepatic metabolism via cytochrome P450 enzymes. Structural alkylation at the 17α position slows hepatic breakdown but increases hepatic strain, making such compounds useful models for hepatotoxicity research.

Endocrine Feedback Mechanisms

Exogenous androgens suppress luteinizing hormone (LH) and follicle‑stimulating hormone (FSH) through negative feedback at the hypothalamus and pituitary, reducing endogenous testosterone production. This mechanism is well established in endocrine studies.

What Studies Have Shown 

Androgenic and Anabolic Research

Studies of DHT‑derived anabolic agents demonstrate increased lean mass, protein synthesis, and nitrogen retention in animal models and clinical settings involving related compounds. These findings form the mechanistic basis for understanding methasterone’s pharmacology.

Hepatic Effects of 17α‑Alkylated Steroids

Clinical and toxicologic literature documents elevated liver enzymes and cholestatic injury associated with oral anabolic steroids. These observations provide important insights into steroid metabolism and hepatotoxic mechanisms.

Cardiovascular and Lipid Research

Research consistently shows reductions in HDL cholesterol and increases in LDL cholesterol in subjects exposed to anabolic steroids. These findings have been used to study mechanisms of atherosclerosis and lipid transport.

Endocrine Suppression

Controlled endocrine studies of anabolic steroids demonstrate suppression of the hypothalamic–pituitary–gonadal axis, decreased endogenous testosterone production, and reversible hypogonadism following cessation.

Muscle Physiology and Hypertrophy

Experimental studies of androgen receptor activation demonstrate increased myonuclear number, enhanced satellite cell activity, and increased muscle fiber cross‑sectional area.

Evidence Synthesis

Overall evidence indicates strong anabolic and androgenic activity, well‑characterized endocrine effects, and predictable metabolic and hepatic responses consistent with other 17α‑alkylated anabolic steroids.

Usage & Quality Compliance 

Superdrol capsules are manufactured under GMP‑aligned conditions. Each batch undergoes:

• Identity testing by HPLC or LC‑MS

• Potency assay

• Residual solvent testing

• Heavy metal analysis

• Microbiological testing

• Stability testing

Research protocols may include monitoring of:

• Hormonal panels (LH, FSH, testosterone)

• Liver function tests (ALT, AST, ALP, bilirubin)

• Lipid profiles

• Hematology parameters

• Cardiovascular markers

Randomized and controlled experimental designs are recommended to ensure reproducibility and safety oversight.

Safety Note

Methasterone and related compounds may cause:

• Elevation of liver enzymes and hepatotoxicity

• Adverse lipid profile changes

• Suppression of endogenous testosterone production

• Increased hematocrit

• Potential cardiovascular strain

Long‑term safety data in humans are limited, and compounds of this class are regulated or prohibited in many jurisdictions. Research involving such agents should be conducted under appropriate ethical and regulatory oversight.

Full Reference List (Clickable Links)

Kicman AT. Pharmacology of anabolic steroids. British Journal of Pharmacology.
https://pubmed.ncbi.nlm.nih.gov/15226172/

Basaria S. Androgen abuse and cardiovascular risk. Journal of Clinical Endocrinology & Metabolism.
https://pubmed.ncbi.nlm.nih.gov/20371619/

Hartgens F, Kuipers H. Effects of androgenic‑anabolic steroids in athletes.
https://pubmed.ncbi.nlm.nih.gov/15248788/

LiverTox: Anabolic Steroids and Liver Injury.
https://www.ncbi.nlm.nih.gov/books/NBK548931/

Nieschlag E, Behre HM. Testosterone and anabolic steroids: clinical pharmacology.
https://pubmed.ncbi.nlm.nih.gov/2104626/

© Paragon Pharmatech — Educational Material 2025. For scientific and educational purposes only.

Remember, this product is intended for research purposes only and should not be used for human consumption without proper medical guidance. As with any supplement, it is important to prioritize your health and safety, and to consult with a healthcare professional if you have any underlying health concerns before incorporating this product into your routine.
This product is not a food product. By acquiring this product, you are in full knowledge that it’s not a food, nor is it for human consumption and it’s for market research purposes only